The C57BL/6 mouse exhibits sporadic congenital portosystemic shunts
نویسندگان
چکیده
Cristina Cudalbu, Valérie A McLin, Hongxia Lei, Joao M.N. Duarte, Anne-Laure Rougemont, Graziano Oldani, Sylvain Terraz, Christian Toso, and Rolf Gruetter Laboratory for Functional and Metabolic Imaging, Center for Biomedical Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Département de l'Enfant et de l'Adolescent, Unité de Gastroentérologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland, University of Geneva, Geneva, Switzerland, University of Lausanne, Lausanne, Switzerland, Service de Pathologie Clinique, Hôpitaux Universitaires de Genève, Geneva, Switzerland, Transplantation Division, Department of Surgery, University of Geneva Hospitals, Geneva, Switzerland, University of Pavia, Pavia, Italy, Unité de radiologie abdominale, Service de Radiologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland, University of Lausanne, University of Geneva, Lausanne, Geneva, Switzerland
منابع مشابه
The C57BL/6J Mouse Exhibits Sporadic Congenital Portosystemic Shunts
C57BL/6 mice are the most widely used strain of laboratory mice. Using in vivo proton Magnetic Resonance Spectroscopy ((1)H MRS), we have repeatedly observed an abnormal neurochemical profile in the brains of both wild-type and genetically modified mice derived from the C57BL/6J strain, consisting of a several fold increase in cerebral glutamine and two fold decrease in myo-inositol. This strik...
متن کاملPulmonary Arterial Hypertension Associated with Congenital Portosystemic Shunts Treated with Transcatheter Embolization and Pulmonary Vasodilators.
Cardiopulmonary abnormalities are often present in patients with liver diseases. We herein report a case of congenital portosystemic shunts complicated by hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PoPH). A 57-year-old woman complained of dyspnea and was subsequently diagnosed with HPS and PoPH caused by congenital portosystemic shunts. Although shunt closure by transcathet...
متن کاملAcquired portosystemic collaterals: anatomy and imaging*
Portosystemic shunts are enlarged vessels that form collateral pathological pathways between the splanchnic circulation and the systemic circulation. Although their causes are multifactorial, portosystemic shunts all have one mechanism in common-increased portal venous pressure, which diverts the blood flow from the gastrointestinal tract to the systemic circulation. Congenital and acquired col...
متن کاملVirulence assessment of a Neospora caninum isolate for inbred C57BL/6 mouse
Neospora caninum (N. caninum) is an apicomplexan parasite and causes abortion and congenital neosporosis in cattle worldwide. In this study, we evaluate the virulence of a N. caninum isolate on mouse strain C57BL/6. Six groups of five mice C57BL/6 were intraperitoneally inoculated with 1 × l07, 1.5 × l07, 2 × l07, 3 × l07 and 4 × l07 tachyzoites and a control inoculum of DMEM, respectively. Cli...
متن کاملA Single-Institution Review of Portosystemic Shunts in Children: An Ongoing Discussion
PURPOSE Review the safety and long-term success with portosystemic shunts in children at a single institution. METHODS An IRB-approved, retrospective chart review of all children ages 19 and undergoing surgical portosystemic shunt from January 1990-September 2008. RESULTS Ten patients were identified, 8 females and 2 males, with a mean age of 15 years (range 5-19 years). Primary diagnoses w...
متن کامل